Protein that reverses muscle aging discovered by biological engineers
[Aug 16, 2022: Cory Nealon, University at Buffalo]
Reverse aging in skeletal muscle cells. (CREDIT: Creative Commons)
A University at Buffalo-led research team has shown that a protein named for the mythical land of youth in Irish folklore is effective at reversing aging in skeletal muscle cells.
Published in Science Advances, the study centers on the protein NANOG, which is derived from Tír na nÓg, a place in Irish lore renowned for everlasting youth, beauty and health.
In a series of experiments, researchers overexpressed NANOG in myoblasts, which are the embryonic precursors to muscle tissue. The myoblasts were senescent, meaning they were no longer able to divide and grow.
The research could help lead to treatments for atherosclerosis, osteoporosis and other age-related disorders (Credit: University of Buffalo)
The overexpression ameliorated some of the primary characteristics associated with age-related deterioration of cells, including autophagy, energy homeostasis, genomic stability, nuclear integrity and mitochondrial function.
This illustration shows a senescent muscle cell (left), including the numerous factors that led to its declining ability to divide and grow. It also shows the same type of cell after the overexpression of NANOG, which reversed many of the factors. (CREDIT: University at Buffalo)
Most notably, NANOG increased the number of muscle stem cells in the muscle of prematurely aging mice. This demonstrated the feasibility of reversing cellular aging in the body without the need to reprogram cells to an embryonic pluripotent state, a process that’s often used in stem cell therapy but runs the risk of tumorigenesis.
Representative picture of a heterozygous LAKI progeria mouse (LmnaG609G/+) and his WT sibling (Lmna+/+) both at the age of 10 months. (CREDIT: Science Advances Research Article)
“Our work focuses on understanding the mechanisms of NANOG’s actions in hopes of discovering druggable targets in signaling or metabolic networks that mimic the anti-aging effects of NANOG.
Fluorescent confocal image of NANOG Polyclonal Antibody. (CREDIT: Abcepta)
Ultimately, the work could help lead to new treatments or therapies that help reverse cellular senescence, and aid the many people suffering from age-related disorders,” says the study’s corresponding author Stelios T. Andreadis, PhD, SUNY Distinguished Professor in the Department of Chemical and Biological Engineering at the UB School of Engineering and Applied Sciences.
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Note: Materials provided above by University at Buffalo. Content may be edited for style and length.
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