Single Blood Test Can Detect More Than 50 Types of Cancer

[Apr 20, 2022: Eric A. Klein]


Study findings confirm that the test is proficient in detecting and classifying cell-free DNA (cfDNA). (CREDIT: Creative Commons)


Researchers are one step closer to making a multi-cancer early detection (MCED) test, that can detect over 50 types of cancer, available to select candidates: those who are age 50 and older, asymptomatic, and considered high risk for the disease.


Findings from the third and final phase of the Circulating Cell-free Genome Atlas (CCGA) study have been published in the Annals of Oncology.


Study findings confirm that the test is proficient in detecting and classifying cell-free DNA (cfDNA), or tumor byproducts deposited in the bloodstream of a person with cancer. The test can also identify the site of the originating tumor, even in patients with no cancer-related symptoms.


 
 

A new cancer screening paradigm


Eric A. Klein, MD, first author of the paper and Chairman Emeritus of the Glickman Urological & Kidney Institute, says these findings corroborate those of a previous CCGA sub-study, but at a larger scale and with an independent validation set. He says these results set the stage for a new cancer screening paradigm.


“With the multi-cancer early detection tests, we have the opportunity to diagnose and treat cancer earlier. Used alongside other screening modalities, this could significantly reduce cancer-related deaths,” he says. For some high-mortality cancers – including liver, pancreatic and esophageal – this is the first screening test available.


Currently, only five cancer screening tests are available for patients in the United States; this includes tests for prostate, lung, breast, colorectal and cervical cancers. They each have limitations, including varying levels of invasiveness, discrepancies in use across clinical practice and high false-positive rates, which can lead to overdiagnosis and overtreatment.


 

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The promise of this new assay is raising hopes that a new paradigm is afoot. It can detect the presence of circulating cfDNA through a single blood draw and is particularly effective when it comes to identifying more lethal and later-stage cancers, believed to have more cfDNA. However, this also underscores the importance of combining the MCED with existing screening tests until further refinements are made. “Prostate cancer, for example, sheds comparatively less DNA than other tumors, making it less likely to be detected by the novel assay,” explains Dr. Klein, a urologic oncologist.


How does it work? A genomic sequencing technology elucidates methylation, or chemical changes in the DNA that control gene expression, coupled with a machine learning application that systematically identifies patterns of irregularities in the DNA indicative of cancer. These patterns provide evidence as to where the cancer orginated and can help guide further diagnostic testing.


GRAIL, Inc. a California-based biotech company, developed the assay and has funded international research efforts. The MCED test is now available in the United States by prescription only.


 
 

Key findings


The study evaluated the performance of the test in two cohorts: individuals already diagnosed with cancer (n = 2,823) and those without a cancer diagnosis (n = 1,254). It detected cancer signals from more than 50 types of cancer across all four stages of disease.

  • The test’s overall sensitivity across cancer types and stages was 51.5%; sensitivity increased with each stage – the more advanced the disease, the more sensitive the test.

  • The average rate of sensitivity in cancers stages I – III was 67.6% in 12 pre-specified cancers (anal, bladder, bowel, esophageal, stomach, head and neck, liver and bile-duct, lung, lymphoma, ovarian, pancreatic, and cancers associated with white blood cells), which account for almost two-thirds of cancer-related deaths in the US.

  • The test’s specificity (also known as false-positive rate) was 99.5%, meaning that it found a false signal for cancer in only 0.5% of those tested.

  • In 88.7% of cases, the test correctly identifies the tissue in which the cancer was located, which could help decrease the time to diagnosis and allow physicians to facilitate treatment with greater efficiency.


 
 

A population-based screening tool?


Dr. Klein says the team is satisfied with the promising findings; they are hopeful that this technology could be extrapolated as a tool for cancer screening at a population level.


In fall 2020, Cleveland Clinic announced that it would begin enrollment for its arm of the PATHFINDER study, of which Dr. Klein is the principal investigator. He explains that the strength of the CCGA study is its robust assessment of the assay itself. The PATHFINDER study, however, is intended to evaluate the care pathways from a cancer “signal detected” test in a primary care setting to arriving at a diagnostic resolution with a cancer specialist.


“We can say with confidence that the multi-cancer early detection test has clinical utility. We still don’t know the implications for its use in a more generalizable patient population, but the results are very promising.”


 
 

The 50 types of cancers tested:


Adrenal Cortical Carcinoma

Ampulla of Vater

Anus

Appendix, Carcinoma

Bile Ducts, Distal

Bile Ducts, Intrahepatic

Bile Ducts, Perihilar

Bladder, Urinary

Bone

Breast

Cervix

Colon and Rectum

Esophagus and Esophagogastric Junction

Gallbladder

Gastrointestinal Stromal Tumor

Gestational Trophoblastic Neoplasms

Kidney

Larynx

Leukemia

Liver

Lung

Lymphoma (Hodgkin and Non-Hodgkin)

Melanoma of the Skin

Mesothelioma, Malignant Pleural

Merkel Cell Carcinoma

Nasal Cavity and Paranasal Sinuses

Nasopharynx

Neuroendocrine Tumors of the Appendix

Neuroendocrine Tumors of the Colon and Rectum

Neuroendocrine Tumors of the Pancreas

Oral Cavity

Oropharynx (HPV-Mediated, p16+)

Oropharynx (p16-) and Hypopharynx

Ovary, Fallopian Tube and Primary Peritoneum

Pancreas, exocrine

Penis

Plasma Cell Myeloma and Plasma Cell Disorders

Prostate

Small Intestine

Soft Tissue Sarcoma of the Abdomen and Thoracic Visceral Organs

Soft Tissue Sarcoma of the Head and Neck

Soft Tissue Sarcoma of the Retroperitoneum

Soft Tissue Sarcoma of the Trunk and Extremities

Soft Tissue Sarcoma Unusual Histologies and Sites

Stomach

Testis

Uterus, Carcinoma and Carcinosarcoma

Uterus, Sarcoma

Ureter (and Renal Pelvis)

Vagina

Vulva




For more science news stories check out our New Innovations section at The Brighter Side of News.


 

Note: Materials provided above by Eric A. Klein. Content may be edited for style and length.


 
 

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Tags: #New_Innovations, #Cancer, #Medical_News, #Blood_Test, #DNA, #Testing, #Science, #Research, #Technology, #The_Brighter_Side_of_News

 

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