Surprising discovery regarding Vitamin D's use for the management of asthma
[Feb. 8, 2023: Harry Dayantis, Cochrane]
The review found no harm in taking vitamin D and it did not examine other possible health benefits. (CREDIT: Creative Commons)
Taking vitamin D supplements does not reduce the risk of asthma attacks in children or adults, according to an updated Cochrane review.
These findings are in contrast to a previous Cochrane review that indicated a reduction in asthma attacks in people taking vitamin D. However, the review found no harm in taking vitamin D and it did not examine other possible health benefits.
The review was carried out by researchers from Queen Mary University of London and the University of Edinburgh. Researcher Adrian Martineau, Clinical Professor of Respiratory Infection and Immunity at Queen Mary University of London, said: “Vitamin D deficiency has been linked to an increased risk of severe asthma attacks and our previous Cochrane review, published in 2016, found that vitamin D reduced the risk of asthma attacks."
"However, more studies have been published since then and when we included the extra data in our updated review, the overall results changed. We found that vitamin D supplements had no effect on risk of asthma attacks or on control of asthma symptoms compared with a placebo”, he continued.
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Professor Martineau and his colleagues analysed the results of 20 randomised controlled trials – the gold-standard for medical research – including data on 1,155 children and 1,070 adults with asthma. This compares to nine trials involving a total of 1,093 people whose data contributed to the previous review. The majority of patients in the trials had mild to moderate asthma.
When they compared patients who were assigned to take a vitamin D supplement with patients who were assigned to take a placebo (dummy medication), the researchers found no statistically significant difference in the number of people who experienced an asthma attack requiring treatment with a course of steroid tablets.
The review did not find any effect of taking vitamin D on asthma control even when people were vitamin D-deficient when they joined the studies, or with different doses of the supplement, or in people of different ages.
Professor Martineau said: “In contrast to our previous Cochrane review on this topic, this updated review does not find that vitamin D offers protection against asthma attacks or improves control of asthma symptoms. However, the trials we looked at did not include many people with severe asthma or people with very low levels of vitamin D in their blood, so these are areas where more research is still needed.
Anne Williamson, the first author on the study who is also from Queen Mary University of London, commented: “We can’t be certain why this updated review has given a different result to our original study from 2016. It could be that people with asthma may be getting better treatment than previously. Or it could be that, in general, rates of vitamin D deficiency have decreased over time, due to increasing intake of supplements or fortified foods. Either of these factors could obscure potential benefits from taking vitamin D supplements. Regardless of the reason, these most recent findings are likely to be correct for people living with asthma today. This also highlights why it’s vital to update reviews when more research is published.”
Today’s review includes data from 20 clinical trials, compared with nine in the 2016 review, and children with asthma are better represented than previously. The review team say they have also applied stricter criteria on which studies would be included, compared to some other reviews. For example, they excluded studies that did not compare vitamin D with a placebo and those that did not monitor patients for at least 12 weeks.
Most of the trials included in the review involved patients taking cholecalciferol, which is the typical form of vitamin D supplement. One trial that used calcidiol, which is a compound that the body can make from vitamin D, reported an improvement in asthma control in patients taking this supplement. The reviewers say further research is needed to confirm whether this form of vitamin D has benefits for people with asthma.
Does vitamin D reduce risk of severe asthma attacks or improve control of asthma symptoms?
1) In contrast to our previous Cochrane Review on this topic, this updated review does not find that vitamin D offers protection against severe asthma attacks or improves control of symptoms.
2) Further trials are required in people with frequent severe asthma attacks and those with very low baseline vitamin D status, and into the potential for calcidiol (a particular form of vitamin D) to offer protective effects.
Why did researchers think that vitamin D might benefit patients with asthma?
Low blood levels of vitamin D (the 'sunshine vitamin') have been linked to an increased risk of severe asthma attacks, defined as those requiring oral (systemic) steroid medications.
Our previous Cochrane Review on this topic in 2016 found that vitamin D reduced the risk of asthma attacks, yet debate has continued, and some subsequent trials found vitamin D to have no effect. We therefore conducted an updated meta‐analysis to include data from new trials completed since our last review.
What did this research want to find out?
We wanted to find out if vitamin D supplementation:
reduces the risk of severe asthma attacks;
improves control of asthma symptoms;
leads to any negative side effects.
What did this research do?
We searched for randomised controlled trials that assessed the effect of vitamin D supplementation on the risk of severe asthma attacks and asthma symptom control. We compared and summarised the results of the studies and rated our confidence in the evidence, based on factors such as study methods.
We also analysed whether effects of vitamin D supplementation differed according to baseline vitamin D status, the dose or form of supplements administered, how often people took the supplements, or the age of participants.
What did the research find?
We included data from 20 clinical trials in this review that involved a total of 2225 people; nine of these were included in the previous Cochrane Review on the topic and 11 were published since then. Of the 20 studies, 15 reported data on severe asthma attacks. The trials lasted between three and 40 months, and all but two investigated a particular form of vitamin D called cholecalciferol or vitamin D3. This is the most common form of vitamin D tablet.
• People given vitamin D supplements did not have a lower risk of severe asthma attacks compared to those given placebo (dummy medication).
• Vitamin D supplementation did not influence measurements of asthma control or breathing capacity; neither did it affect risk of serious harmful side effects.
What are the limitations of the evidence?
• People with severe asthma and those with very low vitamin D levels prior to supplementation were poorly represented, so we cannot assess whether vitamin D supplements might help these individuals.
• A single study investigating effects of calcidiol, an alternative form of vitamin D, showed a protective effect. Further investigation of this form of vitamin D is needed.
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Note: Materials provided by Cochrane. Content may be edited for style and length.
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